Close-up digital rendering of a DNA double helix structure with sparkling particles, symbolizing cellular biology and genetic regulation

What are Sirtuins and Why are They so Important?

Introduction

What Are Sirtuins?

Sirtuins are encoded by the SIRT genes and are NAD+ dependent enzymes, which means that their enzymatic activities depend on the concentration of NAD+ in the organism. Sirtuin gene activity is positively correlated with NAD+ concentration. When NAD+ levels are higher, SIRT activity is also increasing. Sirtuins regulate almost all cellular protein stability by two main processes: Deacetylation which regulates protein production in the cell and the ADP-ribosylation process which changes the structure and activity of the protein.

Diagram of a human cell showing locations of different sirtuins: SIRT1 and SIRT2 in the cytoplasm, SIRT3, SIRT4, and SIRT5 in the mitochondria, and SIRT1, SIRT6, and SIRT7 in the nucleus

Credits: Denu lab

Sirtuins Functions and Longevity.

Sirtuin 1

Sirtuin 2

Sirtuin 3

Sirtuin 4

Sirtuin 5

Sirtuin 6

Sirtuin 7

Conclusion

Hello100 formula contains delayed release NAD+ precursors to boost NAD+ and Liposomal Trans-Resveratrol formula was created to activate SIRTs.

Written By : Dr. Jason Mett