NAD+, or nicotinamide adenine dinucleotide, is a coenzyme that plays a crucial role in various biological processes. It is found in all living cells and is involved in energy metabolism and cellular signaling.

NAD+ functions as an electron carrier, participating in redox reactions in the cell. It can exist in two forms: oxidized (NAD+) and reduced (NADH). NAD+ accepts electrons from other molecules and becomes reduced to NADH, which can then donate those electrons to other molecules.

One of the primary functions of NAD+ is its involvement in cellular respiration, where it plays a vital role in the breakdown of carbohydrates, fats, and proteins to generate energy. It acts as a cofactor for enzymes called dehydrogenases, which catalyze the transfer of electrons during these metabolic processes.

Beyond its role in energy metabolism, NAD+ is also a key player in cellular processes like DNA repair, gene expression, and regulation of cellular stress responses. It is involved in various enzymatic reactions, including those related to sirtuins, a family of proteins associated with aging and longevity.

As we age, NAD+ diminishes. Due to the decline, one might feel frequent fatigue, have metabolic disorders, start gaining weight, and have other age-related disorders and inflammations. This can be associated with cancer, diabetes, heart disease, neurodegenerative diseases (e.g. Alzheimer’s, Parkinson’s disease, dementia), and autoimmune disorders (e.g. rheumatoid arthritis, psoriasis, inflammatory bowel, and multiple sclerosis).

Exercise, good sleep and lengthening the interval between meals can avert age-related issues by enhancing your NAD+ levels. But this alone does not guarantee heightened levels of NAD+.

In addition to these measures you can also take food supplementations and NAD+ boosters which will keep the high NAD+ levels in your body. Hello100 Delayed Release NAD+ is one of the NAD+ boosters that can complement your healthy daily diet.

These are compounds closely related to NAD+ (nicotinamide adenine dinucleotide). Such precursor molecules fuel the body's natural production of NAD+. It is far more superior than direct intake of the NAD+ coenzyme itself, as it usually gets broken down in the stomach, never reaching your bloodstream.

In the process of cellular metabolism, precursors are converted into NAD+ through a series of enzymatic reactions. Once converted to NAD+, they play a vital role as a coenzyme in numerous biological processes, including energy metabolism, DNA repair, and cellular signaling.

They are generally considered to be safe when used appropriately. Studies have shown that oral administration of 100 mg, 250 mg, and 500 mg is well-tolerated and safe. NAD+ supplement consumption does not cause overexpression of nicotinamide the increase of which would cause undesired side effects.

The complex process of aging is influenced by numerous factors. While NAD+ plays a role, it is important to note that it alone cannot address all the hallmarks of aging. With this in mind, we suggest getting Hello100 Delayed Release NAD+ & Resveratrol Bundle, which combines the synergy of both supplements to help mitigate the core damages associated with aging.

Hello100 is dedicated to providing the best quality ingredients and avoiding the addition of any unnecessary fillers. That’s why our Delayed Release NAD+ Capsules only consist of 98% precursor molecules, Sunflower Lecithin, and the Vegetable Cellulose capsule that these two ingredients are filled into.

Hello100 uses the delayed release technology of capsule delivery. The traditional method of capsule intake shows less effectiveness in delivering only 2% of the actual precursors. The delayed release form of the supplement capsule ensures the bioavailability of the NAD+ and that it will enter the cells and reach the targeted tissues.

Liposomal refers to a form of drug or nutrient delivery system that utilizes liposomes, which are microscopic lipid (fat) vesicles. Liposomes are spherical structures composed of a lipid bilayer, similar to the structure of cell membranes. They can encapsulate active substances such as drugs, vitamins, or other compounds within their core or membrane.

The liposomal delivery system offers several advantages for the transportation of these substances:

1. Enhanced bioavailability: Liposomes can protect the encapsulated substance from degradation in the digestive system, allowing for better absorption and utilization by the body. They can help increase the bioavailability of the substance, ensuring that a higher proportion reaches its target tissues.
2. Targeted delivery: Liposomes can be designed to selectively accumulate in specific tissues or cells due to their size, composition, and surface properties. This targeted delivery allows for more efficient and specific action of the encapsulated substance at the desired site, while reducing the potential for off-target effects.
3. Increased stability: Liposomes provide a protective environment for the encapsulated substance, shielding it from degradation by enzymes or harsh environmental conditions. This helps maintain the stability and integrity of the substance, preserving its potency and effectiveness over time.
4. Reduced side effects: Liposomes can minimize direct contact between the encapsulated substance and sensitive tissues, reducing the potential for irritation or adverse reactions. This can help enhance the safety profile of the delivered substance.

Liposomal delivery systems have been extensively studied and applied in various fields, including pharmaceuticals, nutraceuticals, and cosmetics. They offer a promising approach to improve the delivery and effectiveness of active substances, allowing for better therapeutic outcomes and reduced side effects.

At Hello100, we added delayed release technology to our NAD+ supplement to solidify its bioavailability. Hence the necessity to encapsulate it and keep it intact.

Another advantage of capsules is that you can carry them wherever you go. And you can save time and swallow the NAD+ capsules right away without mixing them with yogurt or oil.

The Hello100 NAD+ capsules are small, so you will not feel uncomfortable while swallowing the capsule

There is no specific age when you can start taking NAD+ supplements. Scientists suggest you start paying attention to your body when you notice signs of “bad” aging. NAD+ products work best to mitigate age-related issues and help reverse aging.

The majority of our customers start taking NAD+ supplements when they reach 30+ years.

There is no universally established dosage for NAD+ supplementation, and scientific research on optimal dosages is still ongoing. However, here are some general considerations:

1. Age: Younger individuals may require lower dosages compared to older individuals due to potential differences in metabolism and cellular function. Older individuals may benefit from higher dosages due to potential declines in NAD+ levels associated with aging.
2. Weight: Higher body weight might require slightly higher dosages, but it is not the sole determinant of NAD+ dosage.
3. Start low and gradually increase: It’s often recommended to start with a lower dosage (e.g., 100-250 mg) and observe how your body responds before gradually increasing the dosage if needed.
4. Follow manufacturer recommendations: Different NAD+ products may have their own recommended dosages based on their specific formulation and concentration. It’s crucial to read and follow the instructions provided by the manufacturer.

Remember, discussing your specific situation with a healthcare professional who is familiar with your medical history is the best approach to determine the appropriate NAD+ dosage for you. They can consider your individual needs, health status, and any potential interactions with other medications or supplements you may be taking.

Hello100, we recommend using one capsule a day. The dosage may seem small at first sight. But this is an optimal and positive dosage for the Hello100 NAD+ supplement enhanced with liposomal technology.

Yet, if you want to increase the amount of NAD+ intake consider consulting your doctor beforehand.

Delayed release products compared to traditionally designed ones demonstrate increased bioavailability of 3 to 40x when using delayed release enteric coating in some of the most popular supplements available on the market.

General recommendation is taking NAD+ during the first half of your day.

NAD+ (Nicotinamide Adenine Dinucleotide) levels naturally fluctuate throughout the day, but the highest levels are generally observed during the daytime, specifically in the late morning and early afternoon.

The rise in NAD+ levels is believed to be influenced by various factors, including the body’s circadian rhythm, which regulates physiological processes over a 24-hour period. The circadian rhythm tends to peak during the daytime, leading to increased NAD+ levels.

It’s worth noting that NAD+ levels can be influenced by factors such as diet, exercise, and sleep patterns. Additionally, individual variations in NAD+ levels can exist, so the exact timing and magnitude of peak levels may differ among individuals.

Hello100 Delayed Release NAD+ can be taken both before and after eating. As the Hello100 NAD+ is delayed release, it encounters less barriers on its way to cells.

Hello100 products are created with environmental safety goals in mind. All the ingredients used in our NAD+ capsules are not only third-party tested and approved, but are also vegan.

Hello100 Delayed Release NAD+ is designed and manufactured in an FDA approved facility in the USA.

Hello100 NAD+ product quality is third-party tested and approved. During the 6 months of testing, the NAD+ capsules were stored at three different temperatures. At 104F (40C), room temperature or cold storage conditions showed no significant changes in NAD+ stability and bioavailability.

According to stability tests, when unopened, the shelf life of the NAD+ supplements is at least 2 years. However, we recommend consuming your NAD+ within 6 months once it is opened.

Currently, there are no side effects of NAD+ found by scientists. Research with rodents found no toxicity or side effects from consistent use of NAD+. A single study on humans demonstrated no safety concerns following a dose of 100, 250, and 500 mg of NAD+.

The dosage of NAD+ may vary from person to person. Some people may feel high energy levels after 250mg of NAD+ intake while others may need at least 500mg.

It is typically recommended to start with 250 mg of non-delayed release NAD+ if you are younger than 35 years old. This dose can be doubled to 500 mg  non-delayed release NAD+ daily after 1–2 weeks. If you are 35 or older, it is recommended to start with 500 mg non-liposomal daily and increase to 1000 mg after 1–2 weeks.

Daily dose should be based on how you feel while taking the supplement. So if you feel better on a lower dose, then you should take the lower dose.

Delayed Release NAD+ is equal at least two times non-delayed release NAD+. 200 mg Delayed Release NAD+ is at least 400 – 600 mg non-delayed release NAD+.

The role of nicotinamide adenine dinucleotide (NAD+) in memory improvement is an area of ongoing scientific research.

While NAD's impact on memory has not been extensively studied in humans, some animal studies have shown potential positive effects. For example, a study conducted on mice found that NAD+ administration improved age-related cognitive decline and memory impairments. The mice treated with NAD+ showed enhanced performance in memory tasks compared to the control group.

Some of the improvements with NAD+ are a sharper mind and better concentration. NAD+ enhances blood flow in the brain and further improves cognition.

Additionally, memory is a complex cognitive function influenced by various factors, including genetics, lifestyle, and overall brain health. It is unlikely that NAD+ alone would be a standalone solution for memory improvement. A comprehensive approach, including a healthy lifestyle, regular exercise, a balanced diet, and cognitive stimulation, is generally recommended for maintaining and enhancing cognitive function.

NAD+ can help mitigate fertility issues while aging and revoke the egg cells’ damage.

As David Sinclair states in his reports NAD+ demonstrated beneficial effects on menopausal women. Read more about how can NAD+ improve fertility.

Several studies demonstrate the benefits of NAD+ in the human body including the overall health of the heart, brain, and other organs. The benefits found during the studies are:

• Increased sensitivity to insulin
• Improved mitochondrial function 
• Improved neural function in the brain
• Suppresses adipose tissue inflammation (type 2 diabetes, obesity, cardiovascular diseases), which is caused due to age
• It could help aid weight loss as metabolism improves

The good news is that you can increase NAD+ levels not only with NAD+ supplements but also naturally by exercising and eating balanced food. Plus you can naturally get NAD+ from meat, fish, and some vegetables. Read about these foods here.

NAD+ is a naturally occurring molecule in broccoli, tomato, avocados, edamame, and cucumber. You may consider eating these products instead of taking NAD+ supplements. That can be a good start for healthy eating, but…

The NAD+ in these types of foods is scarce. To get all the NAD+ your body requires, you’d need to eat more than 1kg of them and you’d still get less than in a single capsule. So here come NAD+ supplements as readily available alternatives.

For faster delivery in the USA, we operate two warehouses, one in California and the other in Florida. Additionally, we have a warehouse in the European Union to ensure quicker shipping across all EU countries.

Hello100 doesn’t have retail stores and is not sold in physical stores.

We use UPS and USPS for shipments within the US. In the EU, deliveries are handled by UPS or DPD. For international shipments, we partner with UPS, DHL, and USPS.

International shipping charges cover shipping costs only. Please note that you may be required to pay taxes and duties at your local customs office or post office.

Taxes and duties vary by country and may also depend on the order value. Here are the specifics for the regions we ship to:

- Australia: Customs duties apply to orders over AUD 1,000.

- USA & EU: Since orders are shipped from within these regions, no additional customs charges apply.

- Canada: Customs duties may apply. Taxes and duties vary depending on the order value and local regulations.

When your order is packed and sent for delivery, you will receive a confirmation email with an active link to track your order. Click the link and you will be able to see the status of your order.

Please allow 2 business days for the order tracking information to be updated. After that, you can check the status of your order. We recommend waiting the following times for delivery:

- 2–5 business days for deliveries within the US and EU;
- 1 week for delivery to Canada
- Up to 2 weeks for deliveries to other international locations

Hello100 NAD+ product was tested and guaranteed to be stable under various temperatures. The 6-month storage of the sealed/unopened NAD+ product under 104F (40C) showed significantly unaffected stability.

Hence, thanks to the advanced manufacturing methods, you can be sure that your NAD+ capsules will arrive to you untacked.

Your order may be delayed due to Customs procedures. However, there can also be other unexpected factors affecting the delivery delay. In case of unexpected delays, please contact us and we will try to solve the issue promptly.

Keep in mind international packages are subject to delays due to customs procedures, fees, and taxes that are the responsibility of the consignee.

After your order is placed, there is a limited time (less than 20 mins) to make changes. However,if there is a need to perform order modifications, please contact us at healthy@hello100.com

While this type of issue rarely happens with us, we will help you out if it happens. Simply contact us at: healthy@hello100.com and we will assist you with your order.

If your order was lost or damaged on the way to your destination, you should file a claim for the item and it can be re-shipped.

In case your item was damaged we will need its picture, order number, and shipping label to be able to process the return and re-shipping request. Feel free to contact us at healthy@hello100.com to solve these issues.

As we aim to provide the best possible services for you, we accept orders 24/7. As soon as we receive your order, it is fulfilled within 24 business hours.

You can return your order 60 days after receiving it with the guarantee of a refund. If you are not satisfied with your order you can send it back to us and get a full or 50% refund based on these two cases:

• We will issue a full refund for unopened items returned within 60 days of receiving them.
• We will issue a 50% refund from the purchase price for the items that have at least 50% product remaining in the bottle.

To learn more about the return policy, click here.

Should you have any questions concerning our products, ordering, website issues, navigation, or others, please feel free to contact us via healthy@hello100.com

In case you need immediate assistance with payment, your order, or shipment information, call us at (888) 871-7047.

At Hello100, we offer a one-time 10% discount for subscriptions to our newsletters. Subscribing to our newsletters will also ensure you don’t miss any seasonal discounts, promotions, or product news.

Also, you can join our official subreddit where you can engage in discussions, ask questions and get various useful news. Here you can also find a lifetime 10% discount available  ONLY for the Hello100 subreddit subscribers.

The discount code that you have received through email, found on our official subreddit, Facebook, or Instagram post, can be used at checkout. Simply apply the code before you finish your order and get the promised amount of the discount.